Ann Hasseltine Judson (1789-1826) is the first lady of American missions since she was the first American woman to go overseas as a missionary.

She sailed with her husband, Adoniram, for Calcutta, India, in 1812. Ordered to leave India, they began their missionary work in Rangoon, Burma in 1813. Ann learned the Burmese and Siamese languages, did translation work, taught Burmese girls, and managed her household and cared for her husband during his 18 month imprisonment in 1824-25.